Method of inserting amino acid analogs into proteins

Details Method of inserting amino acid analogs into proteins Method of inserting amino acid analogs into proteins

C - Chemistry, Metallurgy

12

N

195/1.29

C12N 15/00 (2006.01)

Patent

CA 1240941

Abstract of the Disclosure A method for substituting one amino acid for another in a protein chain to improve selected properties of the protein. Initially, an mRNA molecule capable of producing an unmodified protein of the type it is desired to modify is provided. Next the codon along the mRNA chain which ordinarily accepts the anti-codon corresponding to a first amino acid which is to be replaced with a selected second amino acid is determined. The tRNA which ordinarily brings the first amino acid to that site is modified to carry the second amino acid instead. The modified protein is then formed by translation techniques in the presence of the modified tRNA, whereby the second amino acid is incorporated in the protein chain in place of the first amino acid. Several methods of accomplishing the modification of the selected tRNA are also disclosed.

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