A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 9/107 (2006.01)
Patent
CA 2582242
A method of inserting a lipid-linked moiety into a lipid assembly, such as a planar lipid monolayer or bilayer, a spherical lipid vesicle, a micelle, or an emulsion envelope monolayer is described. In the method, the lipid assembly and the lipid~ linked moiety are contacted in the presence of microwave irradiation to permit the lipid-linked moiety to become associated with the lipid assembly. In one embodiment, the lipid assembly is a liposome and the lipid-linked moiety is a lipid~polymer. Compositions comprised of a lipid layer and of a lipid-linked moiety, prepared in accord with the method, are also described.
La présente invention concerne un procédé d~insertion d~un fragment associé aux lipides dans un ensemble lipidique, tel qu~une monocouche ou une bicouche lipidique plane, une vésicule lipidique sphérique, une micelle ou une monocouche d~enveloppe d~émulsion. Dans le procédé, l~ensemble lipidique et le fragment associé aux lipides sont mis en contact en présence d~un rayonnement micro-ondes afin de permettre au fragment associé aux lipides de s~associer à l~ensemble lipidique. Dans un mode de réalisation, l~ensemble lipidique est un liposome et le fragment associé aux lipides est un polymère lipidique. L~invention concerne des compositions comprenant une couche lipidique et un fragment associé aux lipides, préparés conformément au procédé.
Barenholz Yechezkel
Garbuzenko Olga
Alza Corporation
Gowling Lafleur Henderson Llp
LandOfFree
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