C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/87 (2006.01) C12N 15/89 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2443142
The present invention relates to a method of interfering with gene expression in a mammalian past-implantation embryo comprising the step of introducing siRNA molecules or shRNA molecules or DNA molecules encoding siRNA or shRNA molecules wherein said siRNA molecules or said shRNA molecules have a region of identity or of substantial identity of at least 15 nucleotides with the gene(s) the expression of which is to be interfered with into cells of said post- implantation embryo. Additionally, the present invention pertains to a method of performing a genomic-wide functional screen comprising introducing variety of siRNA molecules or shRNA molecules or DNA molecules encoding a variety of siRNA or shRNA molecules wherein said different siRNA or shRNA molecules have a region of identity or substantial identity of at least 15 by with different genes into a mammalian post-implantation embryo.
Buchholz Frank
Calegari Federico
Haubensak Wulf Eckhard
Huttner Wieland B.
Blake Cassels & Graydon Llp
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.v.
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