C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/26 (2006.01) C07K 1/22 (2006.01) G01N 21/17 (2006.01) G01N 33/543 (2006.01) G01N 33/553 (2006.01)
Patent
CA 2198615
The invention concerns a process, a biosensor unit which can be regenerated and suitable kits for investigating the interaction between biomolecules by means of surface plasmon resonance (SPR). One of the reagents, a (poly)peptide, is coupled to the surface of the biosensor unit by means of a metal chelate. Nitrilotriacetic acid derivatives to which proteins with an affinity peptide containg histadine groups can be bonded are preferably used as chelate formers.
L'invention concerne un procédé et une unité de biodétection pouvant être régénérée, ainsi que des matériels appropriés, pour la recherche de l'interaction entre des biomolécules par résonance de plasmon superficiel (SPR). Un des réactifs, un (poly)peptide, est couplé au moyen d'un chélate métallique à la surface de l'unité de biodétection. Les agents de formation de chélate utilisés sont, de préférence, des dérivés d'acide nitrilonitriacétique auxquels peuvent être liées des protéines présentant un peptide d'affinité contenant des radicaux histidine.
Habermann Bianca
Steinlein Peter
Zauner Wolfgang
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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