Method of lithiating five-membered heterocycles

Details Method of lithiating five-membered heterocycles Method of lithiating five-membered heterocycles

C - Chemistry, Metallurgy

07

D

C07D 333/08 (2006.01) C07B 61/00 (2006.01) C07D 207/32 (2006.01) C07D 207/323 (2006.01) C07D 209/08 (2006.01) C07D 277/22 (2006.01) C07D 307/28 (2006.01)

Patent

CA 2347763

The invention relates to a method of lithiating CH-acidic five-membered heterocycles whereby the five-membered heterocylce is reacted with metallic lithium in an ether-containing solvent in the presence of an H acceptor.

L'invention concerne un procédé de lithification d'hétérocycles à cinq chaînons CH-acides, selon lequel l'hétérocycle à cinq chaînons est mis à réagir dans un solvant contenant de l'éther avec du lithium métallique en présence d'un accepteur H.

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