Method of lowering serum cholesterol levels with...

Details Method of lowering serum cholesterol levels with... Method of lowering serum cholesterol levels with...

A - Human Necessities

61

K

A61K 31/695 (2006.01)

Patent

CA 2177968

A method of lowering plasma cholesterol level in a patient with hyercholesterolemia, by administration of a compound of formula (I) wherein: R1, R2, R3 and R4 are each independently a C1-C6 alkyl group; Z is a thio, oxy or methylene group; A is C1-C4 alkylene group; and R5 is a C1-C6 alkyl or -(CH2)n-(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubsubstited or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C1-C6 alkyl.

L'invention se rapporte à un procédé de réduction des taux de cholestérol dans le plasma chez un patient atteint d'hypercholestérolémie, et qui consiste à administrer un composé de la formule (1) dans laquelle R¿1?, R¿2?, R¿3? et R¿4? représentent chacun indépendamment un groupe alkyle C¿1?-C¿6?; Z représente un groupe thio, oxy ou méthylène; A représente un groupe alkylène C¿1?-C¿4?; et R¿5? représente un alkyle C¿1?-C¿6? ou -(CH¿2?)¿n?-(Ar), où n est un nombre entier valant 0, 1, 2 ou 3; et Ar représente phényle ou naphtyle non substitué ou substitué avec un à trois substituants sélectionnés dans le groupe contenant hydroxy, méthoxy, éthoxy, chloro, fluoro ou alkyle C¿1?-C¿6?.

Affiliated with

Also associated with

Rating

Method of lowering serum cholesterol levels with... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of lowering serum cholesterol levels with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of lowering serum cholesterol levels with... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1821400