Method of making a sulfonate ester and cross-linked alcohol...

Details Method of making a sulfonate ester and cross-linked alcohol... Method of making a sulfonate ester and cross-linked alcohol...

C - Chemistry, Metallurgy

12

N

530/17, 195/35,

C12N 11/08 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2004517

"METHOD OF MAKING A SULFONATE ESTER AND CROSS-LINKED ALCOHOL COATED SUPPORT MATRIX" ABSTRACT A support matrix generally useful for the immobilization of biologically active proteins is made by coating a core support with a polymeric alcohol where the core support is titania or titinated alumina or a carbonaceous pyropolymer deposited on a high surface area refractory inorganic oxide, cross-linking the alcohol contained in the resulting coated support; and thereafter converting a portion of the hydroxyl moieties of the resulting crosslinked alcohol coated support to sulfonate esters. Such coated support matrix covalently bind enzymes and antibodies via a strong carbon- nitrogen single bond to give, for example, an immobilized antibody system extremely resistant to leaching of the antibody, the cross-linked alcohol, or of metals from the core support.

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