A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 17/00 (2006.01) A61F 2/24 (2006.01) A61L 27/36 (2006.01) A61L 33/00 (2006.01)
Patent
CA 2174665
A method of treating a collagenous biomaterial, such as porcine aortic valve leaflets or bovine pericardium, by exposing the biomaterial to an alcohol to inhibit in vivo calcification. The biomaterial preferably glutaraldehyde-pretreated, is subjected to an aqueous solution of 60 % to 80 % lower aliphatic alcohol such as ethanol for a period of at least 20 minutes, and preferably, 24 to 72 hours. The biomaterial is rinsed, and then stored in either a glutaraldehyde-free environment or an ethanolic solution of glutaraldehyde.
Procédé de traitement d'un biomatériau à base de collagène tel que des valves de valvules aortiques porcines ou le péricarde bovin, consistant à exposer le biomatériau à un alcool afin d'inhiber la calcification in vivo. Le biomatériau, qui est de préférence prétraité au glutaraldéhyde, est soumis à une solution aqueuse comprenant 60 % à 80 % d'alcool aliphatique inférieur, tel que l'éthanol, pendant une période d'au moins 20 minutes et, de préférence, de 24 à 72 heures. Le biomatériau est rincé, puis stocké dans un environnement dépourvu de glutaraldéhyde ou dans une solution de glutaraldéhyde à l'éthanol.
Hirsch Danielle
Levy Robert J.
Smart & Biggar
The Board Of Regents Of The University Of Michigan
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