Method of making camptothecin and camptothecin analogs

Details Method of making camptothecin and camptothecin analogs Method of making camptothecin and camptothecin analogs

C - Chemistry, Metallurgy

07

D

C07D 491/052 (2006.01) C07D 213/64 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2214037

Compounds of Formula I (see formula I) are made in accordance with the following scheme: (see formula II) wherein R may be loweralkyl; R1 may be H, loweralkyl, loweralkoxy, or halo; R2, R3, R4, and R5 may each independently be H, amino, hydroxy, loweralkyl, loweralkoxy, loweralkylthio, di(loweralkyl)amino, cyano, methylenedioxy, formyl, nitro, halo, trifluoromethyl, aminomethyl, azido, amido, hydrazino, or any of the twenty standard amino acids bonded to the A ring via the amino-nitrogen atom; Y is H and W and X are halogen. Also disclosed are novel processes for making starting materials for the scheme given above, and novel intermediates employed in these processes.

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