Method of making particles for use in a pharmaceutical...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2413692

A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.

La présente invention concerne un procédé permettant de produire des particules composites servant d'excipients destinées à être utilisées dans une composition pharmaceutique, comprenant une étape de broyage durant laquelle des particules d'une substance servant d'excipient sont broyées en la présence d'une substance d'addition. Les particules obtenues sont de petite taille, et le broyage requière relativement peu de temps et d'énergie. Les particules composites peuvent être utilisées dans des compositions pharmaceutiques à inhaler.

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