Method of making particles for use in a pharmaceutical...

Details Method of making particles for use in a pharmaceutical... Method of making particles for use in a pharmaceutical...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/00 (2006.01) A61K 9/72 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2429665

The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.

L'invention concerne un procédé de préparation de particules composites actives à utiliser dans une composition pharmaceutique destinée à une administration pulmonaire. Le procédé comprend une étape de broyage dans laquelle des particules d'une matière active sont broyées en présence de particules d'une matière supplémentaire encourageant la dispersion des particules composites actives au moment de l'activation d'un inhalateur. L'invention concerne également des compositions destinées à l'inhalation et préparées selon l'invention.

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