Method of making polyhydric alcohol solutions of enhanced...

A - Human Necessities – 61 – K

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A61K 8/26 (2006.01) A61K 8/28 (2006.01) A61K 8/34 (2006.01) A61K 8/44 (2006.01) A61Q 15/00 (2006.01)

Patent

CA 2204015

The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5Ø

La présente invention concerne un procédé de préparation d'une solution d'un sel antisudoral d'aluminium à efficacité accrue dans un polyol. Ledit procédé consiste à: (a) utiliser une solution aqueuse composée essentiellement d'environ 5 % à environ 18 % en poids, d'un sel antisudoral d'aluminium à efficacité accrue et d'eau, ledit sel antisudoral d'aluminium à efficacité accrue ayant été préparé in situ sans avoir été séché à l'état de poudre solide; (b) mélanger la solution aqueuse avec une quantité suffisante d'un polyol liquide de façon à obtenir une solution mixte possédant un rapport du sel antisudoral au polyol allant de 1 : 4 environ à 1,2 : 1 environ; (c) et à faire en sorte que l'eau de la solution mixte s'évapore rapidement, sous vide, pour donner une solution finale liquide de polyol contenant environ 20 à 50 % du sel antisudoral d'aluminium à efficacité accrue et environ 2 à 16 % d'eau, le reste étant constitué de polyol. Un sel de glycinate alcalin, tel que le sodium, le potassium ou le glycinate de zinc, peut être ajouté au polyol avant l'addition de la solution de sel antisudoral afin d'augmenter le pH du produit recueuilli jusqu'à environ 4,1 à 5,0.

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