Method of making pteridine compounds

Details Method of making pteridine compounds Method of making pteridine compounds

C - Chemistry, Metallurgy

07

D

260/242.1

C07D 475/08 (2006.01)

Patent

CA 1060010

ABSTRACT OF THE DISCLOSURE A method for the preparation of pteridine compounds such as methotrexate is disclosed. 2,4-diamino-6-pteridine- methanol?HBr is reacted with triphenylphosphine dibromide or phosphorus tribromide to form 6-(bromomethyl)-2,4-diamino- pteridine hydrobromido and the bromine atom in the molecule is then replaced with the functional group, N-[4-(methylamino)- benzoyl]-L-glutamic acid in the case of methotrexate and N-(4-aminobenzoyl)-L-glutamic acid in the case of aminopterin. - 2 -

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