Method of manufacture of 1,3-oxathiolane nucleosides

Details Method of manufacture of 1,3-oxathiolane nucleosides Method of manufacture of 1,3-oxathiolane nucleosides

C - Chemistry, Metallurgy

07

D

C07D 327/04 (2006.01) C07D 411/04 (2006.01) C07D 473/00 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2340214

Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.

L'invention concerne des procédés de préparation de nucléosides de 1,3-oxathiolane comprenant des méthodes efficaces de préparation du noyau de 1,3-oxathiolane et de condensation ultérieure de 1,3-oxathiolane avec une base pyrimidique ou purique. En suivant les procédés selon l'invention, on peut obtenir les composés sous forme d'énantiomères isolés.

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