A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 29/16 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) A61L 29/08 (2006.01) A61L 29/14 (2006.01) A61L 31/10 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2586010
Methods of manufacturing drug-coated medical devices having a porous coatings thereon. The pores are created by solid particle additives added to a mixture comprising a solvent, a drug, and a polymer to create a suspension, which is applied to the medical device. The method includes adding a surfactant to the mixture to prevent or decrease flocculation of the solid particle additives. Another method is provided that includes spraying a suspension on a medical device that comprises solid particle additives, a drug, and a polymer and analyzing the distribution of the solid particle additives in the suspension.
La présente invention concerne des procédés pour fabriquer des dispositifs médicaux présentant un enrobage médicamenteux poreux. Les pores sont créés par des additifs sous forme de particules solides qui sont ajoutés à un mélange comprenant un solvant, un médicament et un polymère afin de créer une suspension qui est appliquée sur le dispositif médical. Le procédé consiste à ajouter un agent tensioactif au mélange afin d'empêcher ou de réduire la floculation des additifs sous forme de particules solides. Un autre procédé consiste à pulvériser une suspension sur un dispositif médical comprenant des additifs sous forme de particules solides, un médicament et un polymère, puis à analyser la distribution des additifs sous forme de particules solides dans la suspension.
Arney Michael
Thiesen-Toupal Jesse Christian
Warner Robert A.
Boston Scientific Limited
Mccarthy Tetrault Llp
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