Method of marking eukaryotic cells by the use of a cell...

Details Method of marking eukaryotic cells by the use of a cell... Method of marking eukaryotic cells by the use of a cell...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2170757

A method of marking a eukaryotic (mammalian) cell by expressing in this cell a nucleic acid, said nucleic acid encoding a cell surface receptor, and by subsequently presenting said receptor at the cell surface, characterized by using a nucleic acid in which the region encoding the intracellular domain of the receptor has been completely or partly deleted or modified in such a way that the receptor presented at the surface cannot, after binding to its binding partner, effect any signal transduction, is effective and usable in gene therapy.

L'invention concerne un procédé de marquage d'une cellule eucaryote (mammifère) consistant à exprimer dans cette cellule un acide nucléique, lequel code un récepteur de surface cellulaire, et ensuite à présenter ce récepteur à la surface cellulaire, ledit procédé étant caractérisé par l'utilisation d'un acide nucléique dans lequel la région codant le domaine intracellulaire du récepteur a été totalement ou partiellement effacée ou modifiée de telle manière que le récepteur présenté à la surface ne peut pas, après liaison avec son partenaire de liaison, effectuer une quelconque transduction du signal. Ce procédé est efficace et on l'utilise en thérapie génique.

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