Method of mass spectrometry and a mass spectrometer

Details Method of mass spectrometry and a mass spectrometer Method of mass spectrometry and a mass spectrometer

H - Electricity

01

J

H01J 49/26 (2006.01) G01N 27/62 (2006.01) G01N 33/48 (2006.01) H01J 49/00 (2006.01) H01J 49/04 (2006.01) H01J 49/16 (2006.01) H01J 49/42 (2006.01)

Patent

CA 2433431

A method of mass spectrometry is disclosed wherein a gas collision cell is repeatedly switched between a fragmentation and a non-fragmentation mode. Parent ions from a first sample are passed through the collision cell and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the collision cell and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.

L'invention concerne un procédé de spectrométrie de masse dans lequel une cellule de collision de gaz est constamment commutée entre un mode de fragmentation et un mode de non- fragmentation. Des ions parents provenant d'un premier échantillon traversent la cellule de collision de gaz, et on obtient un spectre de masse d'ions parents et un spectre de masse d'ions issus de la fragmentation. Des ions parents provenant d'un second échantillon traversent ensuite la cellule de collision de gaz et on obtient un second ensemble de spectre de masse d'ions parents et de spectre de masse d'ions issus de la fragmentation. On compare ensuite les spectres de masse et, lorsque dans les deux exemples, certains ions parents ou certains ions issus de la fragmentation sont exprimés différemment, on effectue une analyse afin de les identifier.

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