Method of mass spectrometry and a mass spectrometer

Details Method of mass spectrometry and a mass spectrometer Method of mass spectrometry and a mass spectrometer

H - Electricity

01

J

H01J 49/26 (2006.01) G01N 27/62 (2006.01) G01N 33/48 (2006.01) H01J 49/00 (2006.01) H01J 49/04 (2006.01) H01J 49/16 (2006.01) H01J 49/42 (2006.01)

Patent

CA 2433434

A method of mass spectrometry is disclosed wherein a gas collision cell is repeatedly switched between a fragmentation and a non-fragmentation mode. Parent ions from a first sample are passed through the collision cell and parent ion mass spectra anal fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the collision cell and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.

Il s'agit d'une méthode de spectrométrie de masse selon laquelle un dispositif de fragmentation est laissé EN MARCHE, de sorte qu'en mode de fragmentation élevée, les ions passent dans le dispositif de fragmentation et sont fragmentés. En mode de fragmentation faible, les ions contournent le dispositif de fragmentation.

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