G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01)
Patent
CA 2500866
A method for conveniently measuring the plasma protein-binding site of a drug having a binding affinity for plasma protein and the effect of the binding substitution thereof, and application of the same to clinical diagnosis. That is to say, it is intended to provide a method which comprises reacting a first drug, the binding site of which on plasma protein is to be measured, with a second drug, the binding site of which on plasma protein is already known, and plasma protein and then measuring a change in the release ratio of the first drug due to the binding of the second drug to plasma protein to thereby measure the binding site of the first drug on the plasma protein.
L'invention concerne un procédé permettant de mesurer de manière pratique le site de liaison de protéine de plasma d'un médicament présentant une affinité de liaison pour une protéine de plasma et l'effet de la substitution de liaison de celui-ci, ainsi que son application à un diagnostic clinique. L'invention concerne un procédé consistant à faire réagir un premier médicament dont le site de liaison sur la protéine de plasma doit être mesuré, avec un second médicament, dont le site de liaison sur la protéine de plasma est déjà connu, et une protéine de plasma, puis à mesurer un changement dans le rapport de libération du premier médicament en raison de la liaison du second médicament à la protéine de plasma pour mesurer le site de liaison du premier médicament sur la protéine de plasma.
Kawai Keiichi
Takamura Norito
Marks & Clerk
Nihon Medi-Physics Co. Ltd.
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