Method of measuring neprilysin activity

Details Method of measuring neprilysin activity Method of measuring neprilysin activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) C12Q 1/37 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2483525

It is intended to provide a method of measuring neprilysin activity, etc. More specifically speaking, it is intended to provide: a method of measuring neprilysin activity in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin in nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. A compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring neprilysin activity as described above, is useful as a preventive and/or a remedy for Alzheimer~s disease. The above method of measuring the activity is usable in diagnosing Alzheimer~s disease.

L'invention concerne une méthode permettant de mesurer l'activité de la néprilysine, etc. Plus spécifiquement, cette invention a trait à une méthode permettant de mesurer l'activité de la néprilysine dans des cellules nerveuses, à une méthode de criblage d'une protéine, d'un peptide ou d'un composé améliorant l'activité ou l'expression de la néprilysine dans des cellules nerveuses par le biais de la mesure de l'activité de la néprilysine, à une méthode d'amélioration de l'activité ou de l'expression de la néprilysine etc. On utilise un composé améliorant l'activité ou l'expression de la néprilysine comme agent préventif et/ou remède à la maladie d'Alzheimer, ledit composé étant obtenu par le procédé de criblage caractérisé par l'utilisation de la méthode de mesure de l'activité de la néprilysine susmentionnée. On peut employer la méthode susmentionnée de mesure de l'activité dans le diagnostic de la maladie d'Alzheimer.

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