Method of mitigating the adverse effects of interleukin-2

Details Method of mitigating the adverse effects of interleukin-2 Method of mitigating the adverse effects of interleukin-2

A - Human Necessities

61

K

A61K 31/35 (2006.01) C07D 311/58 (2006.01) C07D 311/66 (2006.01)

Patent

CA 2339947

A method and composition for mitigating the adverse effects of Interleukin-2 (IL-2) on a subject is disclosed. The method involves administering an amount of a leukotriene receptor antagonist to a subject exhibiting adverse pharmacological effects due to exogenous IL-2, where the amount administered to the subject is sufficient to decrease the IL-2 induced adverse effects. Also disclosed is an article of manufacturing comprising a composition of the leukotriene receptor antagonist in combination with labeling instructions for treatment. Also disclosed is a method for preparing a pharmaceutical composition.

L'invention concerne un procédé et une composition destinés à atténuer les effets secondaires de l'interleukine-2 (IL-2), chez un sujet. Ce procédé comprend l'étape consistant à administrer une dose d'un antagoniste du récepteur des leucotriènes à un sujet présentant des effets secondaires pharmacologiques consécutifs à la prise d'IL-2 exogène, la dose de l'antagoniste administrée à ce sujet étant suffisante pour diminuer les effets secondaires induits par IL-2. L'invention concerne également un article de fabrication comprenant une composition de l'antagoniste du récepteur des leucotriènes, en combinaison avec des instructions de marquage servant au traitement. L'invention concerne encore un procédé de préparation d'une composition pharmaceutique.

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