A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7125 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2229171
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen- mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immuno-stimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
La présente invention concerne un procédé permettant de réduire les effets immunostimulateurs de certains oligonucléotides de phosphorothioate utilisés dans le traitement de maladies liées à des pathogènes et d'autres états médicaux. Conformément au procédé de la présente invention, on réduit les effets immunostimulateurs des oligonucléotides de phosphorothioate en modifiant au moins une structure chimique à l'intérieur de l'oligonucléotide de phosphorothioate que l'on peut ensuite administrer à un mammifère atteint par la maladie ou le trouble que l'on traite. Le procédé de cette invention permet également de surveiller la réponse immunitaire dudit mammifère.
Agrawal Sudhir
Temsamani Jamal
Zhao Qiuyan
Hybridon Inc.
Idera Pharmaceuticals Inc.
Mbm Intellectual Property Law Llp
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