Method of modulating hypothalamic somatostatin release

Details Method of modulating hypothalamic somatostatin release Method of modulating hypothalamic somatostatin release

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2282323

This invention relates generally to a method for modulating hypothalamic somatostatin release in a mammal in need of such treatment by administration of a therapeutically effective amount of a leptin receptor ligand. The present invention also relates to a method of modulating plasma levels of growth hormone, thyroxine, and tri-iodothyroxine by administration of a therapeutically effective amount of a leptin receptor ligand, or specific antibodies to leptins.

La présente invention concerne principalement un procédé permettant de stimuler la libération de la somatostatine par l'hypothalamus d'un mammifère nécessitant un tel traitement. Le procédé consiste en l'occurrence en l'administration d'une quantité, suffisante d'un point de vue thérapeutique, d'un ligand du récepteur de la leptine. L'invention concerne également un procédé de modulation des niveaux d'hormone de croissance, de thyroxine et de tri-iodothyroxine et consistant en l'administration d'une quantité, suffisante d'un point de vue thérapeutique, d'un ligand du récepteur de la leptine ou d'anticorps spécifiques des leptines.

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