Method of modulating mammalian t-cell response

Details Method of modulating mammalian t-cell response Method of modulating mammalian t-cell response

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2106567

2106567 9216234 PCTABS00016 Methods of modulating mammalian T-cell response restricted by an MHC and methods of treating an MHC-linked disease in a mammal suspected of requiring such modulation or treatment, are provided by the invention. The methods comprise treating the mammal or contacting the T-cells respectively with an effective amount of a peptide, which peptide has an amino acid sequence substantially corresponding to at least a portion of the antigen recognition site of said MHC, or a peptide mimetic wherein said peptide or peptide mimetic is capable of binding with a T-cell antigen receptor which unbound T-cell antigen receptor is capable of recognizing said MHC bound to an antigen.

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