Method of modulating stress-activated protein kinase system

Details Method of modulating stress-activated protein kinase system Method of modulating stress-activated protein kinase system

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61K 31/4412 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/706 (2006.01) C07D 213/70 (2006.01) C07D 213/80 (2006.01) C07D 215/227 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2608116

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

La présente invention concerne des procédés permettant de moduler le système des protéines kinases activées par le stress ou "SAPK" (Stress Activated Protein Kinase) en utilisant un composé actif à faible potentiel d'inhibition d'au moins une protéine kinase activée par le mitogène p38 et par le stress ou "p38MAPK" (p38 Mitogen Activated Protein Kinase). La mise en contact se fait à une concentration de modulation SAPK qui correspondant à une basse concentration inhibitrice pour l'inhibition du p38MAPK considéré par le composé. L'invention concerne également des dérivés de pirfénidone capables de moduler un système de SAPK.

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