A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/45 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2464606
The present invention relates generally to a method of modulating the immunoactivity of a population of immune cells and, more particularly to a method of down-regulating the immunoactivity of an immunocompetent graft. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate graft immunoactivity such as, but not limited to, the prophylaxis treatment of graft versus host disease in allogeneic stem cell graft recipients.
La présente invention se rapporte en général à une méthode permettant de moduler l'activité immunitaire d'une population de cellules immunitaires, et, plus précisément, à une méthode permettant de diminuer l'activité immunitaire d'un greffon immunocompétent. La méthode selon la présente invention est utile, entre autres, dans le traitement et/ou la prophylaxie d'états caractérisés par une activité immunitaire aberrante, non souhaitée ou inappropriée du greffon, tels que, de façon non limitative, le traitement prophylactique de la réaction de greffe contre hôte observée chez des receveurs d'une greffe de cellules souches allogènes.
Hart Derek Nigel John
Hill Geoffrey Roger
Macdonald Kelli Patricia Anne
Fetherstonhaugh & Co.
The Corporation Of The Trustees Of The Order Of The Sisters Of M
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