Method of monitoring the effect of cathepsin s inhibitors

Details Method of monitoring the effect of cathepsin s inhibitors Method of monitoring the effect of cathepsin s inhibitors

G - Physics

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N

G01N 33/564 (2006.01) C12Q 1/37 (2006.01) G01N 33/535 (2006.01) G01N 33/545 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2421558

The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed patients.

L'invention concerne un procédé relatif au contrôle de l'effet de l'administration in vivo d'inhibiteurs de cathepsine S, qui consiste à mesurer l'accumulation d'un produit de dégradation intermédiaire de chaîne invariante (Ii), en particulier le fragment p10 Ii, dans le sang des patients auxquels une dose est administrée.

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