Method of obscuring immune recognition

Details Method of obscuring immune recognition Method of obscuring immune recognition

A - Human Necessities

61

L

A61L 33/00 (2006.01) A61K 9/00 (2006.01) A61L 15/32 (2006.01) A61L 27/22 (2006.01) A61L 27/26 (2006.01) A61L 27/38 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61K 35/12 (2006.01) A61K 47/18 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2337047

The present invention provides a method of obscuring immune recognition of a transplant by a host mammal by encapsulating tissue suitable for use in a transplant within a hydrogel matrix, wherein the hydrogel matrix comprises gelatin, dextran, at least one nitric oxide inhibitor, and an effective amount of polar amino acids. The matrix binds to the cell surface proteins of the tissue and obscures recognition of the tissue by high affinity antibodies produced by the recipient of the transplant.

L'invention concerne un procédé empêchant la reconnaissance immunitaire d'un greffon par masquage, par un mammifère hôte, par encapsulation d'un tissu approprié pour implanter un greffon dans une matrice d'hydrogel. Cette matrice d'hydrogel comprend de la gélatine, un dextrane, au moins un inhibiteur d'acide nitrique, et une quantité efficace d'acides aminés polaires. La matrice se lie aux protéines cellulaires de surface du tissu, et empêche la reconnaissance de ce tissu par masquage, par des anticorps à affinité élevée produits par le récepteur du greffon.

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