Method of obtaining citalopram

Details Method of obtaining citalopram Method of obtaining citalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01)

Patent

CA 2474323

The invention relates to a method of obtaining purified citalopram or the salts thereof. The inventive method consists in purifying citalopram using selective extractions of citalopram or the impurities of same with organic dissolvents and water under determined pH and temperature conditions. The crude citalopram can be obtained by means of a method consisting in reacting 1- [3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide.

L'invention concerne un procédé d'obtention de citalopram purifié ou de ses sels. Ce procédé consiste à purifier le citalopram par extractions sélectives du citalopram ou de ses impuretés au moyen de dissolvants organiques et d'eau dans des conditions déterminées de pH et de température. Le citalopram cru peut s'obtenir par un procédé qui consiste à faire réagir 1-[3-(diméthylamino)propyl]-1-(4-fluorophényle)-1,3-dihydro-5-bromoisobenzofurane avec du cyanure de cuivre.

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