C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) A61K 35/407 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2492905
The present invention is directed toward a method for obtaining from whole liver or a resection thereof a population of cells comprising viable, functional liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells, compositions thereof, and uses therefore. Compositions include a composition of liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells and a pharmaceutical composition thereof. Uses include treatment of liver diseases, regeneration of liver, toxicity testing and liver assist devices.
Cette invention se rapporte à un procédé permettant d'obtenir à partir de foie entier ou d'une résection de foie entier une population de cellules comprenant des cellules de foie fonctionnelles viables enrichies en hépatocytes et en cellules souches/précurseurs d'hépatocytes, à des compositions de ces cellules et à des utilisations de celles-ci. Cette invention concerne de telles compositions, notamment une composition de cellules de foie enrichies en hépatocytes et en cellules souches/précurseurs d'hépatocytes, ainsi qu'une composition pharmaceutique de celles-ci. Cette invention trouve des applications dans le traitement des maladies du foie, dans la régénération du foie, dans les tests de toxicité et dans les dispositifs d'assistance du foie.
Bruce Andrew T.
Furth Mark E.
Ludlow John W.
Reid Lola M.
Susick Robert L. Jr.
Mbm Intellectual Property Law Llp
University Of North Carolina At Chapel Hill
Vesta Therapeutics Inc.
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