Method of omeprazole preparation

Details Method of omeprazole preparation Method of omeprazole preparation

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2265538

The invention solves a method of preparation of omeprazole by a reaction of 5- methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimidazole with peroxyacetic acid in a two-phase water and chlorinated organic solvent medium, in alkaline pH, subsequent separation of water and organic phases after the reaction and isolation of omeprazole from organic phase.

L'invention concerne un procédé de préparation d'omeprazole consistant à faire réagir 5-méthoxy-2-[(4-méthoxy-3,5-diméthyl-2-pyridinyl)-méthylthio]-1H-benzimidazole avec l'acide peroxyacétique dans un milieu renfermant de l'eau diphasique et un solvant organique chloré, à pH alcalin, à effectuer la séparation des phases aqueuse et organique après la réaction et à isoler l'omaprazole de la phase organique.

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