Method of packaging and sterilization of a pharmaceutical...

Details Method of packaging and sterilization of a pharmaceutical... Method of packaging and sterilization of a pharmaceutical...

B - Operations, Transporting

65

B

156/1, 217/36, 2

B65B 55/02 (2006.01) B65B 11/52 (2006.01) B65D 75/36 (2006.01)

Patent

CA 1317571

IMPROVED METHOD OF PACKAGING AND STERILIZING A PHARMACEUTICAL PRODUCT Abstract of the Disclosure A method of filling, sealing and sterilizing a pharmaceutical package including a polypropylene bottle containing a balanced salt solution includes the steps of filling each bottle to maximum capacity to exclude residual air, the introduction of a silicone rubber gasket into the bottle cap to absorb pressure and prevent leakage during a steam sterilization procedure, and the enclosure of the filled bottles in a blister pack before steam sterilizing. The blister packs have Tyvekm lids and are placed blister-side-up during the sterilization process to eliminate deformation of the blister during sterilization. Maximum filling of the bottle with liquid and the substantial elimination of air prevents dimpling of the bottle.

584771

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