B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 2/04 (2006.01) A61K 9/16 (2006.01) B05D 1/02 (2006.01)
Patent
CA 2376593
The invention provides a method for forming particles of a target substance, comprising (a) co-introducing into a particle formation vessel, under controlled temperature and pressure, a supercritical or near-critical anti-solvent fluid; a "target solution or suspension" of the target in a first vehicle; and a second vehicle which is soluble in the anti-solvent fluid; and (b) using the anti-solvent to disperse the target solution/suspension and the second vehicle, and to extract the vehicles, substantially simultaneously and substantially immediately on introduction of the fluids into the particle formation vessel, wherein the second vehicle is immiscible with the first, and wherein contact between the target solution/suspension and the second vehicle occurs a sufficiently short period of time before their dispersion by the anti-solvent, and with sufficient physical mixing, as to allow only insignificant, if any, phase separation to occur between the two vehicles between their contact with one another and their dispersion.
L'invention concerne un procédé de formation de particules d'une substance cible. Le procédé consiste : (a) à introduire, en même temps, dans une cuve de formation de particules, à une température et à une pression commandées, un fluide anti-solvant supercritique ou presque critique ; </= une solution ou une suspension cible >/= de la cible dans un premier véhicule ; et un second véhicule soluble dans le fluide anti-solvant ; et (b) à utiliser l'anti-solvant pour disperser la solution/suspension cible et le second véhicule, et pour extraire les véhicules, sensiblement en même temps et sensiblement au moment de l'introduction des fluides dans la cuve de formation de particules, le second véhicule étant immiscible avec le premier, et le contact entre la solution/suspension cible et le second véhicule intervenant suffisamment avant leur dispersion par l'anti-solvant, et dans des conditions de mélange physique suffisantes pour permettre une phase de séparation insignifiante ou inexistante entre les deux véhicules lors de leur contact l'un avec l'autre et lors de leur dispersion.
Hanna Mazen Hermiz
York Peter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Bradford Particle Design Ltd.
Nektar Therapeutics Uk Ltd.
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