C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) A61K 38/51 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2422890
The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Aklylating agents, used for the treatment of certain types of tumors including tumors of the nervous system and lymph system, are efficacious agents when the damage they do to tumor cell DNA is not repaired by cellular DNA repair mechanisms. The present invention provides a method for determining the activity of a gene encoding a DNA repair enzyme, thus providing a prediction of the clinical response to alkylating agents. Figure (1) shows the overall survival among subjects with gliomas treated carmustine, and the time of progression of disease according to the methylation status of the MGMT promoter.
L'invention concerne des méthodes liées au traitement chimiothérapeutique d'un trouble de la prolifération cellulaire. L'invention concerne notamment une méthode permettant de prédire la réaction clinique à certains types d'agents chimiothérapeutiques. Les agents alkylants, utilisés pour le traitement de certains types de tumeurs parmi lesquelles des tumeurs du système nerveux et du système lymphatique, sont des agents efficaces lorsque les dommages qu'ils causent à l'ADN de cellules tumorales ne sont pas réparés par les mécanismes de réparation de l'ADN cellulaire. L'invention concerne en outre une méthode permettant de déterminer l'activité d'un gène codant pour une enzyme de réparation de l'ADN, fournissant ainsi une prédiction de la réaction clinique à des agents alkylants.
Baylin Stephen B.
Esteller Manel
Herman James G.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
LandOfFree
Method of predicting the clinical response to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of predicting the clinical response to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of predicting the clinical response to... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1729395