Method of predicting the responsiveness oa a tumor to erbb...

Details Method of predicting the responsiveness oa a tumor to erbb... Method of predicting the responsiveness oa a tumor to erbb...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2574311

The invention relates to a method of selecting a mammal having or suspected of having a tumour for treatment with an erbB receptor drug which comprises testing a biological sample from the mammal for expression of any one of the genes listed in Table 1 or 2 as defined herein whereby to predict an increased likelihood of response to the erbB receptor drug. Preferred genes include any one of NES, GSPT2, ETR101, TAZ, CHST7, DNAJC3, NPAS2, PIN1, TCEA2, VAMP4, DAPK1, DAPK2, MLLT3, TNNC1, KIAA0931, ACOX2, EMP1, SLC20A1, SPRY2 or PGM1.

L'invention porte sur un procédé de sélection d'un mammifère atteint ou susceptible d'être atteint d'une tumeur à traiter au moyen d'un médicament récepteur erbB. Ce procédé consiste à tester un échantillon biologique prélevé sur le mammifère en vue de l'expression de n'importe lequel des gènes indiqués dans les Tableaux 1 ou 2 tels que définis ci-après, afin d'estimer une meilleure probabilité de réponse au médicament récepteur erbB. Les gènes préférés contiennent indifféremment NES, GSPT2, ETR101, TAZ, CHST7, DNAJC3, NPAS2, PIN1, TCEA2, VAMP4, DAPK1, DAPK2, MLLT3, TNNC1, KIAA0931, ACOX2, EMP1, SLC20A1, SPRY2 ou PGM1.

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