C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01)
Patent
CA 2100909
HOE 92/S 012 Abstract of the Disclosure Method of preparation of physostigmine carbamate derivatives from eseretholes This application relates to a new process for the preparation of a product of the formula Image (I) wherein R is loweralkyl; R1 is hydrogen, loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, lowerbicycloalkyl, aryl or arylloweralkyl; R2 is loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, lowerbicycloalkyl, aryl or arylloweralkyl; or R1 and R2 taken together with the nitrogen atom to which they are attached from a 3,4-dihydro-2(1H)-isoquinoline group; X is loweralkyl, loweralkoxy, halogen or trifluoromethyl; and m is 0,1 or 2; which process comprises (a) contacting a compound of formula II Image (II) wherein R, X and m are as defined above and R3 is loweralkyl, with aluminum chloride followed by tartaric acid to afford a compound of formula III Image (III) wherein R, X and m are as defined above; (b) contacting the reaction mixture containing the compound of Formula III either (1) with an isocyanate of the formula R1NCO and obtaining a product of the formula I wherein R2 is hydrogen; or (2) with a compound of formula IV Image (IV) wherein R4 is hydrogen or loweralkyl in the presence of a carboxylic acid of theformula R5COOH wherein R5 is loweralkyl to afford a compound of formula V (V) Image wherein R,R4,X and m are as above; contacting the reaction mixture containing the compound of Formula V with a compound of the formula R1R2NH wherein R1 and R2 are as above; and isolating the product of Formula I.
Lee Thomas B. K.
Weiberth Franz
Wong George S. K.
Bereskin & Parr
Hoechst Marion Roussel Inc.
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