C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
204/91.05, 260/6
C07C 401/00 (2006.01) C07D 237/26 (2006.01) C07D 487/04 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1327977
ABSTRACT: The invention relates to a method of preparing 1.alpha.-hydroxyvitamin D or 1.alpha.-hydroxy-previtamin D compounds by hydroxylating the 1.alpha.-position of an adduct of a previtamin D compound with a suitable dienophile, in which adduct op- tionally present hydroxy group or hydroxy groups is or are protected, if desired, and after removal of the protecting group or groups, isolating the 1.alpha.-hydroxyvitamin D or 1.alpha.-hydroxy-previtamin D compound. The invention also relates to 1.alpha.-hydroxy-previ- tamin D compounds. The invention further relates to an adduct of a previtamin D or tachysterol compound with a dienophile of the general formula Image in which A' and B' are equal and represent methoxy groups or ethoxy groups, or in which A' and B' together constitute a phenylimino or o-phenylene group.
407425
de Clercq Pierre J.
Halkes Sebastianus J.
Overbeek Wilhelmus R. M.
Vandewalle Maurits
Vanmaele Luc J.
Duphar International Research B.v.
Fetherstonhaugh & Co.
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