Method of preparing...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01) C07D 207/14 (2006.01)

Patent

CA 2748066

Methods of preparing (+)-1, 4-dihydro-7-[(3S,45)-3-methoxy-4-(methylamino)-1 - pyrrolidinyl]-4-oxo-1-(2-thia- zolyl)-1,8-naphthyridine-3-carboxylic acid are disclosed. Also provided are pharmaceutical compositions comprising (+)-1,4-di- hydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2- thiazolyl)-1,8-naphthyridine-3-carboxylic acid, and methods of treatment using such compositions.

Linvention concerne des procédés de préparation dacide (+)-1-dihydro-7-[(3s,4s)-3-méthoxy-4-(méthylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphtyridine-3-carboxylique. Linvention concerne également des compositions pharmaceutiques comprenant de lacide (+)-1,4-dihydro-7-[(3s,4s)-3-méthoxy-4-(méthylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphtyridine-3-carboxylique, et des procédés de traitement utilisant de telles compositions.

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