Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and...

Details Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and... Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2536530

The present invention provides a method of preparing a 4-(arylmethyl)amino-1H~- imidazo(4,5-c)quinoline of formula (4) by reacting an arylmethylamine of formula (3) with a 4-chloro-lH-imidazo(4,5-c)quinoline of formula (2). The present invention further provides a method of preparing an acid addition salt of formula (5) comprising the step of hydrolyzing a 4-(arylmethyl)amino- 1 H- imidazo(4,5-c)quinoline of formula (4) with a strong acid, HX The present invention further provides a method of preparing a 4~amino- 1H-imidazo(4,5- c)quinoline of formula (1) comprising the step of treating an acid 10 addition salt of formula (5) with a base.

L'invention concerne un procédé de préparation d'une 4-(arylméthyl)amino-1H--imidazo(4,5-c)quinoline de formule (4) consistant à faire réagir une arylméthylamine de formule (3) avec une 4-chloro-lH-imidazo(4,5-c)quinoline de formule (2). L'invention concerne également un procédé de préparation d'un sel d'ajout acide de formule (5) comprenant l'étape consistant à hydrolyser une 4-(arylméthyl)amino- 1 H-imidazo(4,5-c)quinoline de formule (4) au moyen d'un acide fort, HX. L'invention concerne également un procédé de préparation d'une 4-amino- 1H-imidazo(4,5-c)quinoline de formule (1) comprenant l'étape consistant à traiter un sel d'ajout acide de formule (5) au moyen d'une base.

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