C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/109
C07D 501/12 (2006.01)
Patent
CA 1079720
Abstract of the Disclosure Essentially crystalline cephalothin sodium for parenteral administration is prepared by a freeze-drying process wherein a (C1-C3 alcohol or acetone)-water solution of cephalothin sodium containing from 2 to 10 percent of a C1-C3 alcohol or acetone by volume is chilled from room temperature to -20°C., or below, preferably -40°C. over a 1-3 hour period and then warmed to from -3°C. to -10°C. and held for 3 hours or more, then cooled to -20°C, or below, preferably -40°C., before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents. Alternatively, from 2 to 5 percent by weight of sodium bicarbonate, related to the amount of cephalothin sodium present, is added to the solution before freeze-drying.
291717
Cise Michael D.
Roy Michael L.
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