Method of preparing a rapidly dissolving powder of sterile...

Details Method of preparing a rapidly dissolving powder of sterile... Method of preparing a rapidly dissolving powder of sterile...

C - Chemistry, Metallurgy

07

D

260/109

C07D 501/36 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1097341

Abstract of the Disclosure Essentially crystalline cefazolin sodium (7- (1-(1H)-tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thia- diazolyl)thiomethyl]-3-cephem-4-carboxylic acid, sodium salt, a standard antibiotic) for parenteral administration is prepared by a freeze-drying process wherein an ethanol- water solution of cefazolin sodium is chilled slowly from room temperature to -10°C. over a 3-12 hour-period, and then rapidly cooled until the mixture is completely solidified before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in accept- able pharmaceutical diluents. X-4494

291616

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