Method of preparing a vaccine against hepatitis b and the...

Details Method of preparing a vaccine against hepatitis b and the... Method of preparing a vaccine against hepatitis b and the...

A - Human Necessities

61

K

167/130

A61K 39/29 (2006.01) C07K 14/02 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1306689

ABSTRACT OF THE DISCLOSURE In a method for preparing a vaccine against hepatitis B, surface antigene particles (HBsAg) of the hepatitis B virus are produced by expression from a CHO cell culture transfected by a plasmid by recovering the culture supernatant which, after sterilizing filtration, is concentrated and subjected to a precipitation fractionated with PEG, the precipitate obtained being subjected to rate zonal centrifugation then to isopycnic zonal flotation type centrifugation, following which chromatography is carried out in an anion exchange medium. The vaccine is remarkable by its purity and its immunogenicity, particularly by its anti-pre S2 antibody inducing power.

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