C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 231/12 (2006.01) C07C 235/58 (2006.01)
Patent
CA 2361716
The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a "protected/activated salicylamide"). The method comprises the steps of (a) alkylating the protected/activated salicylamide with an alkylating agent to form a protected/activated alkylated salicylamide, and (b) deprotecting and deactivating the protected/activated alkylated salicylamide, simultaneously or in any order, to form the alkylated salicylamide. The alkylated salicylamides prepared by this method are suitable for use in compositions for delivering active agents via oral or other routes of administration to animals.
La présente invention concerne un procédé permettant de préparer un salicylamide alkylé à partir d'un salicylamide protégé et activé (désigné ci-après par </= salicylamide protégé/activé"). Le procédé de l'invention consiste à : (a) alkyler le salicylamide protégé/activé au moyen d'un agent alkylant afin de former un salicylamide alkylé protégé/activé et (b) déprotéger et désactiver le salicylamide alkylé protégé/activé, simultanément ou dans n'importe quel ordre, pour former le salicylamide alkylé. Les salicylamides alkylés préparés selon ce procédé peuvent être utilisés dans des compositions destinées à administrer, par voie orale ou autre, des principes actifs à des animaux.
Bay William E.
Bernadino Joseph N.
Gschneidner David
Emisphere Technologies Inc.
Na
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