Method of preparing .alpha.-1-proteinase inhibitor

Details Method of preparing .alpha.-1-proteinase inhibitor Method of preparing .alpha.-1-proteinase inhibitor

C - Chemistry, Metallurgy

07

K

530/9

C07K 9/00 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1286848

Abstract of the Disclosure There is disclosed a method for separating alpha-1- proteinase inhibitor (also known as alpha-1 antitrypsin) from an aqueous solution of plasma proteins, especially from Cohn Effluent II & III and Cohn Effluent I. The method includes the steps of first treating the aqueous solution to lower the concentration of salts therein and, optionally, its alcohol content, contacting the resulting solution with an anion exchange resin having selective affinity for alpha-1-proteinase inhibitor to selectively bind the alpha-1-proteinase inhibitor and allow unwanted plasma proteins to elute through the resin, displacing the alpha-1-proteinase inhibitor from the resin and recovering the same. CL-119

521806

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