Method of preparing and intravenously administrable immune...

Details Method of preparing and intravenously administrable immune... Method of preparing and intravenously administrable immune...

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 16/06 (2006.01)

Patent

CA 1112166

ABSTRACT OF THE DISCLOSURE: A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin- containing fraction is freed from undesired protein impuri- ties by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-con- taining fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treat- ment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from portein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharma- ceutical preparation.

335211

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