Method of preparing anti-inflammatory antirheumatic compounds

Details Method of preparing anti-inflammatory antirheumatic compounds Method of preparing anti-inflammatory antirheumatic compounds

C - Chemistry, Metallurgy

07

D

260/207.1

C07D 403/12 (2006.01) C07D 295/088 (2006.01) C07D 295/14 (2006.01)

Patent

CA 1053663

ABSTRACT Anti-inflammatory antirheumatic compounds having the formula: Image (A) wherein n1 and n2 are 2 or 3, are prepared by reacting 5-methoxy-2-methyl-3-indolyl acetic acid with an N-hydroxyalkyl- N'-chloroalkyl-piperazine in an organic solvent in the presence of a condensation agent, to obtain the corresponding N'- (2 or 3)-chloroalkyl-N-(2 or 3)-(5-methoxy-2-methyl-3- indoleacetoxy)-alkyl-piperazine, amidating the N-atom in the indole group in the resulting compound by means of p-chloro-benzoyl chloride to obtain the corresponding N'-(2 or 3)- chloroalkyl-N-(2 or 3)-[1-(p-chlorobenzoyl)-5-methoxy-2- methyl-3-indoleacetoxy]-alkyl-piperazine and reacting the latter compound with N-benzoyl-N',N'-di-n-propyl-DL-isoglutamine in an organic solvent in the presence of a stoichiometric amount of sodium bicarbonate.

231281

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