Method of preparing biological materials and preparation...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/50 (2006.01) A23L 1/305 (2006.01) A61K 9/14 (2006.01) A61K 47/36 (2006.01) C07K 1/00 (2006.01) C12N 1/04 (2006.01) C12N 9/98 (2006.01) A23J 3/00 (2006.01) A23P 1/04 (2006.01) C07K 17/04 (2006.01) C12N 11/04 (2006.01)

Patent

CA 2435888

Methods for preparing products containing moisture-sensitive materials, including biological materials such as proteins, peptides or live cells, comprising at least the steps: (i) providing a coating liquid comprising at least one active, a sugar polymer and a water soluble/miscible solvent; (ii) providing a quantity of microparticles comprising at least water soluble gel forming solid particles; (iii) fluidizing said quantity of microparticles within a processing chamber of a of a suitable apparatus to form a fluidized bed of said microparticles; (iv) spraying said coating liquid onto said fluidized bed from beneath the fluidized bed to coat said microparticles therewith under saturated moisture conditions; and (vi) allowing coated microparticles to dry, are described. Also described are compositions and uses.

L'invention porte sur des procédés de préparation de produits contenant des matériaux sensibles à l'humidité dont des matériaux biologiques tels que des protéines, des peptides, ou des cellules vivantes comprenant au moins les étapes suivantes: (i) prendre un liquide d'enrobage comprenant au moins un actif, un polymère de sucre et un solvant soluble ou miscible dans l'eau; (ii) prendre une quantité de microparticules comprenant au moins des particules solides de gel hydrosoluble; (iii) fluidifier ladite quantité de microparticules dans la chambre de traitement d'un appareil adéquat pour former un lit fluidisé de microparticules; (iv) pulvériser le liquide d'enrobage sur le lit fluidisé depuis le dessous pour enrober lesdites microparticules dans des conditions de saturation d'humidité; (v) faire sécher les microparticules. L'invention porte également sur des compositions et leurs utilisations.

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