Method of preparing clarithromycin

Details Method of preparing clarithromycin Method of preparing clarithromycin

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01)

Patent

CA 2391145

Clarithromycin can be easily prepared by reacting erythromycin A N-oxide with a methylating agent to obtain 6-O-methylerythromycin A N-oxide; and treating 6- O-methylerythromycin A N-oxide obtained above with a reducing agent in a high yield.

La présente invention concerne l'élaboration de la clarithromycine à partir de N-oxyde d'érythromycine A que l'on fait réagir avec un agent de méthylation de façon à obtenir un N-oxyde de 6-O-méthylérythromycine A. Il ne reste plus qu'à traiter au moyen d'un réducteur à grand rendement le N-oxyde de 6-O-méthylérythromycine A obtenu précédemment.

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