Method of preparing clopidogrel and intermediates used therein

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01)

Patent

CA 2612996

Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.

La présente invention concerne du clopidogrel optiquement pur qui peut être préparé à rendement élevé par la résolution optique d'une forme racémique du composé de formule (II) en utilisant une amine optiquement active pour préparer la forme optiquement active du composé de formule (III) ou son sel d'addition d'acide et en méthylant le composé de formule (III) ou son sel d'addition d'acide.

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