Method of preparing d(-)-.beta.-hydroxyisobutyric acid by...

C - Chemistry – Metallurgy – 12 – P

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C12P 13/04 (2006.01) C12P 7/42 (2006.01)

Patent

CA 1239361

ABSTRACT METHOD OF PREPARING D(-)-.beta.- HYDROXYISOBUTYRIC ACID BY FERMENTATION A method is provided for preparing D(-)-.beta.-hydroxyisobutyric acid by fermentation employing isobutyryl chloride or the methyl and/or ethyl esters of isobutyric acid or the methyl and/or ethyl esters of methacrylic acid and/or the acetate and/or formate esters of isobutyl alcohol and/or isobutyl isobutyrate or isobutyl methacrylate as the substrate and a microorganism of the genus Candida and other fungi. In an alternative method, the isolated cells of the various microorganisms are employed with one or mixtures of the above substrates.

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